Androgen withdrawal improves tumor hypoxia in prostate cancer

Around one-quarter of patients who receive radical treatment for prostate cancer subsequently develop progressive disease. The mechanisms underlying this malignant progression are, however, poorly elucidated. Recently, Milosevic and co-workers have investigated the effects of androgen withdrawal on prostate cancer hypoxia. Androgen withdrawal is known to result in tumor regression in the majority of patients, and is effective in combination with radiotherapy.